Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis
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چکیده
منابع مشابه
TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins
We previously showed that mutations in LIS1 and DCX account for approximately 85% of patients with the classic form of lissencephaly (LIS). Some rare forms of LIS are associated with a disproportionately small cerebellum, referred to as lissencephaly with cerebellar hypoplasia (LCH). Tubulin alpha1A (TUBA1A), encoding a critical structural subunit of microtubules, has recently been implicated i...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2007
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4402216